DSIP (Delta Sleep-Inducing Peptide)
Also known as: Delta sleep-inducing peptide, DSIP, Emideltide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, Deltaran
DSIP is a nonapeptide, meaning a small chain of nine amino acids, first isolated in the 1970s by Swiss researchers from the cerebral venous blood of rabbits during sleep. Its name comes from early findings that it appeared to increase delta-wave activity on EEG recordings, the brain-wave pattern associated with deep sleep. It occurs naturally in the body, though where it is made and how it is regulated remain unclear.
How it works
The mechanism of DSIP is not well understood, and after decades of study its specific receptor, gene, and site of synthesis have not been identified. Preclinical research, mostly in animal models, has explored possible interactions with GABAergic signaling, the hypothalamic-pituitary-adrenal (stress) axis, cortisol and ACTH regulation, and NMDA-linked pathways. These are proposed mechanisms drawn from laboratory work, not established modes of action in humans.
Researched uses
- Studied for insomnia and slow-wave sleep, with conflicting results
- Studied for opioid and alcohol withdrawal symptoms in small trials
- Studied for stress response and cortisol regulation
- Studied for chronic pain and antinociception in animal models
- Studied for narcolepsy and depression
- Studied for chemotherapy-related central nervous system effects (as the experimental formulation Deltaran)
DSIP is not approved by the FDA for any use. There is no FDA-approved branded DSIP product. It is classified as investigational and is used in research settings. As of mid-2026, DSIP (under the name Emideltide) is a nominated bulk drug substance under review by the FDA Pharmacy Compounding Advisory Committee, which is scheduled to evaluate in July 2026 whether it should be added to the Section 503A list that would permit compounding by licensed pharmacies. That review is pending and no decision has been made, so no established legal compounding pathway exists at this time. Products sold online as DSIP "for research use only" are unregulated, fall outside the licensed pharmacy system, and are not quality-controlled medicines.
DSIP (Delta Sleep-Inducing Peptide) providers compared
Providers that have passed our rubric review are listed first, then ordered by the total cost of a 3-month protocol. We average every cost to a standard 3-month protocol, which our medical advisors consider the best basis for comparing cost and value, and the headline figure folds in any one-time consult or provider-review fee plus three months of membership. Use the calculator below to adjust the length and see the same total broken out.
| Provider | Sourcing | What's included | Verified | Visit provider | |
|---|---|---|---|---|---|
RxPepsDirectVerified DSIP | 503A pharmacy | $279 for 3 months (est.) ≈3 vials · $80/vial incl. $39 consult | Consult fee extra · no membership | Jul 8, 2026 vial price | View |
Ellie MDVerified DSIP Injection | 503A pharmacy | $522 for 3 months $174 per month | No consult fee · no membership · shipping included | Jul 7, 2026 | View |
Valhalla VitalityVerified DSIP Injectable Therapy | 503A pharmacy | $600 for 3 months (est.) ≈3 vials · $199.99/vial | No consult fee · no membership | Jul 9, 2026 vial price | View |
We average every cost to a standard 3-month protocol, which our medical advisors consider the best window for comparing cost and value. Monthly plans are multiplied by 3 and 3-month programs are taken as billed; each provider's own sticker price and cadence are shown underneath.
The headline figure is the total 3-month cost: the medication plus any one-time consult or provider-review fee (for example RxPepsDirect's $39) and three months of any membership fee. Where a fee is not published we fold in what is known and flag that other fees may apply.
Per-vial providers are averaged to a 3-month protocol at roughly one vial per month (3 vials), marked "est.", with the per-vial price shown underneath. Actual vial count depends on your dose and protocol.
Prices are gathered from each provider's public pages. The "Verified" date is when we last checked the provider's sticker price; for per-vial providers it is the vial price that was verified, not the averaged 3-month total.
Value check: total cost of therapy
This is the real value comparison. A sticker price hides consult and membership fees, so this adds everything up for a full protocol of DSIP (Delta Sleep-Inducing Peptide) and ranks by true total cost. We default to a 3-month protocol, the window our medical advisors consider best for judging value.
Per-vial providers are estimated at about one vial per month (3 vials for 3 months), plus any one-time consult. Actual vial count depends on your dose and protocol, so the real cost may run higher or lower.
Safety notes
The human safety profile of DSIP is not well characterized because published trials have been small, older, and inconsistent, and no large controlled safety studies exist. Reported effects in early research were generally mild, but the absence of rigorous long-term data means adverse effects are not well defined. Because DSIP is not sold through the licensed pharmacy system, products marketed online can vary in identity, purity, and dose, and may contain contaminants or amounts that differ from the label.
DSIP (Delta Sleep-Inducing Peptide) questions
How much does DSIP (Delta Sleep-Inducing Peptide) cost?
Across the licensed providers tracked here, a full 3-month protocol of DSIP (Delta Sleep-Inducing Peptide) totals $279 to $600, depending on the provider, dose, and what is included. We average every cost to a standard 3-month protocol, which our medical advisors consider the best basis for comparing cost and value, and the total folds in any one-time consult or provider-review fee and three months of membership. Each price shows the date the provider's sticker price was verified.
Is DSIP an approved sleep medication?
No. DSIP is not approved by the FDA or, to public knowledge, by any national drug regulator for insomnia or any other condition. It is considered investigational. Early research reported effects on delta-wave sleep, but controlled human trials have been limited and their results conflicting.
What does current research say about how well DSIP works?
The clinical evidence is weak and inconsistent. Much of the data comes from small studies or animal models conducted decades ago. Researchers have not established a clear receptor or mechanism, and the peptide has a very short half-life in the body. It remains an area of scientific interest rather than a proven therapy.
How is DSIP obtained and does it cost much?
There is no FDA-approved DSIP product to prescribe or purchase through normal pharmacy channels. It is under FDA compounding review as of 2026, but no legal compounding pathway is established yet. Material sold online for research use is unregulated and outside the licensed pharmacy system, so its identity, quality, and pricing are not verified. Questions about legitimate access should be directed to a licensed clinician.
Related reading
- How to Get Peptides Safely and LegallyHow to get peptides through the legal, licensed pathway: prescriptions, 503A/503B pharmacies, honest evidence, and how to avoid the research-use-only gray market.
- Is Peptide Therapy Right for You?An independent guide to weighing peptide therapy: legality, what the research actually shows, who should avoid it, and how to find safe, licensed care.
- Peptides Studied for Energy and PerformanceAn independent look at CJC-1295, ipamorelin, and MOTS-c for energy and performance: what the research shows, safety and legality, and how to find licensed care.