Epithalon
Also known as: Epitalon, Epithalone, AEDG peptide, Ala-Glu-Asp-Gly, Alanyl-glutamyl-asparagyl-glycine
Epithalon is a synthetic tetrapeptide with the sequence alanine-glutamic acid-aspartic acid-glycine (AEDG). It was developed by a research group led by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, and is described as a synthetic analog of epithalamin, a natural pineal gland extract. It is studied as a research compound rather than being used as a licensed drug.
How it works
Laboratory research suggests that Epithalon may influence gene expression and has been reported in cell-culture studies to increase the activity of telomerase, the enzyme that maintains telomeres at the ends of chromosomes. Proposed mechanisms also include effects on the pineal gland and melatonin regulation. These mechanisms come largely from a single research group and from in vitro and animal work, and their relevance to humans is not established.
Researched uses
- Studied for effects on telomerase activity and telomere length in cell culture
- Studied for lifespan and aging markers in animal models
- Studied for markers of immune and endocrine function in aging
- Studied for melatonin and circadian rhythm regulation
- Studied for antioxidant-related markers in preliminary work
Epithalon is not approved by the FDA for any use. It has no FDA-approved brand-name product. It is used as a research-only compound and is not an approved medicine. Epithalon is not included on the FDA's list of bulk drug substances that may be used in compounding under Section 503A, so it cannot be legally compounded by licensed pharmacies; its bulk-substance status has been the subject of FDA review. There is no legitimate prescription pathway for Epithalon. Products marketed online as Epithalon "for research use only" are outside the regulated pharmacy system and are not quality-controlled for human use.
Epithalon providers compared
Providers that have passed our rubric review are listed first, then ordered by the total cost of a 3-month protocol. We average every cost to a standard 3-month protocol, which our medical advisors consider the best basis for comparing cost and value, and the headline figure folds in any one-time consult or provider-review fee plus three months of membership. Use the calculator below to adjust the length and see the same total broken out.
| Provider | Sourcing | What's included | Verified | Visit provider | |
|---|---|---|---|---|---|
RxPepsDirectVerified Epithalon | 503A pharmacy | $279 for 3 months (est.) ≈3 vials · $80/vial incl. $39 consult | Consult fee extra · no membership | Jul 8, 2026 vial price | View |
Valhalla VitalityVerified Epitalon Therapy | 503A pharmacy | $537 for 3 months (est.) ≈3 vials · $179/vial | No consult fee · no membership | Jul 9, 2026 vial price | View |
We average every cost to a standard 3-month protocol, which our medical advisors consider the best window for comparing cost and value. Monthly plans are multiplied by 3 and 3-month programs are taken as billed; each provider's own sticker price and cadence are shown underneath.
The headline figure is the total 3-month cost: the medication plus any one-time consult or provider-review fee (for example RxPepsDirect's $39) and three months of any membership fee. Where a fee is not published we fold in what is known and flag that other fees may apply.
Per-vial providers are averaged to a 3-month protocol at roughly one vial per month (3 vials), marked "est.", with the per-vial price shown underneath. Actual vial count depends on your dose and protocol.
Prices are gathered from each provider's public pages. The "Verified" date is when we last checked the provider's sticker price; for per-vial providers it is the vial price that was verified, not the averaged 3-month total.
Value check: total cost of therapy
This is the real value comparison. A sticker price hides consult and membership fees, so this adds everything up for a full protocol of Epithalon and ranks by true total cost. We default to a 3-month protocol, the window our medical advisors consider best for judging value.
Per-vial providers are estimated at about one vial per month (3 vials for 3 months), plus any one-time consult. Actual vial count depends on your dose and protocol, so the real cost may run higher or lower.
Safety notes
Published human safety data are limited and come mostly from a single research group; reported side effects in those studies were described as mild and infrequent, such as injection-site reactions. Long-term safety in broad populations has not been established through large independent controlled trials. Because Epithalon sold online is not made or tested within the licensed pharmacy system, identity, purity, sterility, and dose of such products cannot be assured, which adds risk of contamination or mislabeling.
Epithalon questions
How much does Epithalon cost?
Across the licensed providers tracked here, a full 3-month protocol of Epithalon totals $279 to $537, depending on the provider, dose, and what is included. We average every cost to a standard 3-month protocol, which our medical advisors consider the best basis for comparing cost and value, and the total folds in any one-time consult or provider-review fee and three months of membership. The providers listing Epithalon sell it by the vial, so the 3-month figure is an estimate of about one vial per month; the exact vial count depends on your dose and protocol. Each price shows the date the provider's sticker price was verified.
Is Epithalon an approved drug?
No. Epithalon is not approved by the FDA for any medical use. There is no FDA-approved Epithalon product, and it is treated as a research-only compound rather than an approved medicine.
What does the research actually show?
Most published research comes from one Russian research group and includes cell-culture, animal, and small human studies reporting effects on telomerase activity and aging markers. Independent replication and large controlled human trials are limited, so its effects in people remain unproven and investigational.
Can I get Epithalon through a pharmacy, and what about products sold online?
No. Epithalon is not on the FDA's list of bulk drug substances eligible for compounding under Section 503A, so licensed pharmacies cannot legally compound it, and there is no approved or prescription pathway to obtain it. Products sold online as research chemicals fall outside the regulated pharmacy system and are not quality-controlled or verified for human use.
Related reading
- How to Get Peptides Safely and LegallyHow to get peptides through the legal, licensed pathway: prescriptions, 503A/503B pharmacies, honest evidence, and how to avoid the research-use-only gray market.
- Peptides Studied for Longevity and Anti-AgingAn independent look at peptides studied for longevity (GHK-Cu, epithalon, MOTS-c, humanin), what the research shows, and how to find safe, legal care.