PT-141
Also known as: Bremelanotide, Vyleesi (FDA-approved brand), PT141
PT-141, known generically as bremelanotide, is a synthetic cyclic peptide. It is a structural analog of alpha-melanocyte-stimulating hormone (alpha-MSH) and is chemically related to melanotan II. It acts on melanocortin receptors in the central nervous system rather than on blood vessels, which distinguishes it from the PDE5 inhibitor drugs used for erectile function.
How it works
Research describes bremelanotide as a non-selective agonist at melanocortin receptors, with activity at the MC4 and MC3 receptor subtypes thought to be most relevant to sexual response. It is believed to act on neural pathways in the central nervous system involved in sexual desire and arousal, a mechanism separate from the vascular action of PDE5 inhibitors. The full details of how this central activity translates to changes in desire are not completely understood.
Researched uses
- Studied for acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women
- Studied for erectile dysfunction in men (earlier investigational programs)
- Studied for general low sexual desire and arousal
- Investigated in earlier research for other melanocortin-related effects
Bremelanotide is FDA-approved under the brand name Vyleesi, approved in June 2019 for acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. It is a prescription product administered by subcutaneous injection using a single-use autoinjector. Use for any other purpose, including erectile dysfunction in men or use in postmenopausal women, is off-label or investigational and not FDA-approved. PT-141 or "bremelanotide" products sold online as peptides "for research use only" are not the FDA-approved medicine, are not evaluated by the FDA for safety, quality, or purity, and fall outside the licensed pharmacy system.
PT-141 providers compared
Providers that have passed our rubric review are listed first, then ordered by the total cost of a 3-month protocol. We average every cost to a standard 3-month protocol, which our medical advisors consider the best basis for comparing cost and value, and the headline figure folds in any one-time consult or provider-review fee plus three months of membership. Use the calculator below to adjust the length and see the same total broken out.
| Provider | Sourcing | What's included | Verified | Visit provider | |
|---|---|---|---|---|---|
RxPepsDirectVerified PT-141 (Bremelanotide) | 503A pharmacy | $264 for 3 months (est.) ≈3 vials · $75/vial incl. $39 consult | Consult fee extra · no membership | Jul 8, 2026 vial price | View |
Valhalla VitalityVerified PT-141 (Bremelanotide) Therapy | 503A pharmacy | $537 for 3 months (est.) ≈3 vials · $179/vial | No consult fee · no membership | Jul 9, 2026 vial price | View |
Ellie MDVerified PT-141 | 503A pharmacy | $717 for 3 months $239 per month | No consult fee · no membership · shipping included | Jul 7, 2026 | View |
We average every cost to a standard 3-month protocol, which our medical advisors consider the best window for comparing cost and value. Monthly plans are multiplied by 3 and 3-month programs are taken as billed; each provider's own sticker price and cadence are shown underneath.
The headline figure is the total 3-month cost: the medication plus any one-time consult or provider-review fee (for example RxPepsDirect's $39) and three months of any membership fee. Where a fee is not published we fold in what is known and flag that other fees may apply.
Per-vial providers are averaged to a 3-month protocol at roughly one vial per month (3 vials), marked "est.", with the per-vial price shown underneath. Actual vial count depends on your dose and protocol.
Prices are gathered from each provider's public pages. The "Verified" date is when we last checked the provider's sticker price; for per-vial providers it is the vial price that was verified, not the averaged 3-month total.
Value check: total cost of therapy
This is the real value comparison. A sticker price hides consult and membership fees, so this adds everything up for a full protocol of PT-141 and ranks by true total cost. We default to a 3-month protocol, the window our medical advisors consider best for judging value.
Per-vial providers are estimated at about one vial per month (3 vials for 3 months), plus any one-time consult. Actual vial count depends on your dose and protocol, so the real cost may run higher or lower.
Safety notes
Clinical trials of the approved product reported nausea as the most common side effect, along with flushing, injection-site reactions, and headache. The drug can cause a transient rise in blood pressure with a compensatory decrease in heart rate, so it is not recommended for people with uncontrolled high blood pressure or known cardiovascular disease. Focal darkening of the skin (hyperpigmentation), including on the face, gums, and breasts, has been reported, and may not fully resolve; the risk appears greater with repeated use. Products sold outside the licensed pharmacy system as research peptides carry additional risk because their identity, purity, dose accuracy, and sterility are not verified.
PT-141 questions
How much does PT-141 cost?
Across the licensed providers tracked here, a full 3-month protocol of PT-141 totals $264 to $717, depending on the provider, dose, and what is included. We average every cost to a standard 3-month protocol, which our medical advisors consider the best basis for comparing cost and value, and the total folds in any one-time consult or provider-review fee and three months of membership. Each price shows the date the provider's sticker price was verified.
Is PT-141 an FDA-approved drug?
Yes, in one specific form. Bremelanotide is FDA-approved as the brand Vyleesi for hypoactive sexual desire disorder in premenopausal women. Peptide products labeled PT-141 and sold online for research use are not the approved medicine and are not FDA-evaluated.
How is it taken?
The approved product is given as a subcutaneous injection using a prefilled single-use autoinjector, under the direction of a prescriber. This entry does not provide doses or a regimen; those decisions belong to a licensed clinician.
How does the cost or availability compare to other options?
Cost and access vary by product, prescriber, insurance coverage, and pharmacy. The FDA-approved branded product is available only by prescription. Products sold as research peptides are unregulated, so their pricing does not reflect any verified quality standard. A licensed clinician or pharmacist can explain current options.
Related reading
- Peptide Therapy vs TRT: An Honest ComparisonAn independent, evidence-honest look at how TRT and peptide therapy differ on FDA status, research, fertility, safety, and finding legal, prescription-based care.
- Is Peptide Therapy Right for You?An independent guide to weighing peptide therapy: legality, what the research actually shows, who should avoid it, and how to find safe, licensed care.