Semax / Selank
Also known as: Semax/Selank, Semax and Selank nasal spray, nootropic peptide stack
Semax / Selank is a marketing name for a blend of two peptides developed in Russia and often sold together as a nasal spray. Semax is a synthetic fragment related to ACTH studied for cognitive and neuroprotective effects, and Selank is a synthetic analog of the immune peptide tuftsin studied for anxiety and calm. Both are used in Russia and some neighboring countries but are not approved drugs in the United States. Sold together they are marketed as a nootropic stack, and the blend's effects are the combined effects of its two components.
What's in this blend
Semax / Selank combines the following peptides. The blend's effects and risks are those of its components together; open each for its own evidence and safety.
How it works
Semax is reported in laboratory and animal research to influence BDNF and other neurotrophic signaling involved in learning and neuroprotection. Selank is studied for effects on GABA and serotonin systems and on immune signaling, which researchers have linked to anxiety and stress responses. Most of this work is preclinical or comes from small studies outside the US, and the Semax/Selank combination has not been evaluated as a single product in controlled US trials.
Researched uses
- Marketed for focus, memory, and mental clarity (the Semax component)
- Marketed for anxiety, stress, and calm without sedation (the Selank component)
- Used as a nootropic nasal-spray stack, though the combination is unproven in controlled US research
Neither component is FDA-approved in the United States, and there is no FDA-approved Semax/Selank product. Semax is registered as a pharmaceutical in Russia and Selank has been used regionally there, but that status does not apply in the US, where both are sold as research chemicals and are not established compounding substances. Semax in particular has been placed by the FDA in a category that effectively bars compounding, so the legal pathway is not clear-cut; review each provider's own sourcing.
Semax / Selank providers compared
Providers that have passed our rubric review are listed first, then ordered by the total cost of a 3-month protocol. We average every cost to a standard 3-month protocol, which our medical advisors consider the best basis for comparing cost and value, and the headline figure folds in any one-time consult or provider-review fee plus three months of membership. Use the calculator below to adjust the length and see the same total broken out.
| Provider | Sourcing | What's included | Verified | Visit provider | |
|---|---|---|---|---|---|
RxPepsDirectVerified Semax/Selank Nasal Spray | 503A pharmacy | $489 for 3 months (est.) ≈3 vials · $150/vial incl. $39 consult | Consult fee extra · no membership | Jul 8, 2026 vial price | View |
We average every cost to a standard 3-month protocol, which our medical advisors consider the best window for comparing cost and value. Monthly plans are multiplied by 3 and 3-month programs are taken as billed; each provider's own sticker price and cadence are shown underneath.
The headline figure is the total 3-month cost: the medication plus any one-time consult or provider-review fee (for example RxPepsDirect's $39) and three months of any membership fee. Where a fee is not published we fold in what is known and flag that other fees may apply.
Per-vial providers are averaged to a 3-month protocol at roughly one vial per month (3 vials), marked "est.", with the per-vial price shown underneath. Actual vial count depends on your dose and protocol.
Prices are gathered from each provider's public pages. The "Verified" date is when we last checked the provider's sticker price; for per-vial providers it is the vial price that was verified, not the averaged 3-month total.
Value check: total cost of therapy
This is the real value comparison. A sticker price hides consult and membership fees, so this adds everything up for a full protocol of Semax / Selank and ranks by true total cost. We default to a 3-month protocol, the window our medical advisors consider best for judging value.
Per-vial providers are estimated at about one vial per month (3 vials for 3 months), plus any one-time consult. Actual vial count depends on your dose and protocol, so the real cost may run higher or lower.
Safety notes
The safety of the Semax / Selank blend has not been established in controlled US trials. Most human experience comes from use in Russia rather than from large randomized studies, and long-term safety data is limited. Combining two investigational peptides compounds that uncertainty, and composition varies by provider. Products sold outside the licensed pharmacy system are not verified for identity, purity, or sterility.
In the news
- Inside the booming, gray-market world of injectable peptides The Hill
Reporting on the gray market for research-use-only injectable peptides sold outside the licensed pharmacy system, and the associated health concerns.
Semax / Selank questions
How much does Semax / Selank cost?
Across the licensed providers tracked here, a full 3-month protocol of Semax / Selank totals $489 to $489, depending on the provider, dose, and what is included. We average every cost to a standard 3-month protocol, which our medical advisors consider the best basis for comparing cost and value, and the total folds in any one-time consult or provider-review fee and three months of membership. The providers listing Semax / Selank sell it by the vial, so the 3-month figure is an estimate of about one vial per month; the exact vial count depends on your dose and protocol. Each price shows the date the provider's sticker price was verified.
What is Semax / Selank?
It is a blend of two Russian-developed peptides, Semax (studied for focus and neuroprotection) and Selank (studied for anxiety and calm), often sold together as a nasal spray. Doses and ratios vary by provider.
Is it FDA-approved?
No. Neither Semax nor Selank is FDA-approved in the United States. They are used in Russia, but in the US they are sold as research chemicals, and the blend is investigational.
How is it taken?
It is most often sold as a nasal spray. Any specific regimen should be directed by a licensed clinician; this page does not provide dosing.